Cornifelin (CNFN)

By differential screening of cDNA libraries from normal and psoriatic human skin in order to search for genes upregulated in psoriatic skin, Michibata et al. (2004) cloned CNFN.The deduced 112-amino acid protein has a calculated molecular mass of 12.3 kD and shares 97% amino acid identity with mouse Cnfn. Northern blot analysis detected a 0.7-kb transcript in human uterus, cervix, and fetal skin only. Michibata et al. (2004) stated that Robinson et al. (1997) obtained an amino acid sequence ARELKIRE by cyanogen bromide treatment of cornified envelope fragments that matches the C-terminal sequence of CNFN. Michibata et al. (2004) suggested that CNFN is a component of the cornified envelope and may be crosslinked to other components