Cysteine Rich With EGF Like Domains Protein 1 (CRELD1)

Epidermal growth factor (EGF)-like repeats are a class of cysteine-rich domains that mediate interactions between proteins of diverse function. EGF domains are found in proteins that are either completely secreted or have transmembrane regions that tether the protein to the cell surface. CRELD1 is the founding member of a family of matricellular proteins.The full-length clone encodes a deduced 420-amino acid protein. Structural analysis suggested that CRELD1 is a cell adhesion molecule that contains an N-terminal signal sequence; 2 type III transmembrane domains separated by a short cytoplasmic loop; a tandem array of EGF-like repeats; and a region rich in glutamate and tryptophan residues. It also has 2 putative N-linked glycosylation sites and several possible serine, threonine, and tyrosine phosphorylation sites.