Cytochrome C1 (CYC1)

Cytochrome c1 is one of the subunits of the cytochrome bc1 complex of the mitochondrial electron-transfer chain. It mediates the transfer of an electron from Rieske iron-sulfur protein to cytochrome c. Nishikimi et al. (1987) isolated a cDNA clone for cytochrome c1 from a human liver cDNA library and determined its nucleotide sequence. Nishikimi et al. (1988) used the cloned cDNA for Southern hybridization analysis to localize the CYC1 gene to chromosome 8 using a panel of human-mouse somatic cell hybrids. Nishikimi et al. (1988) reported also the sequence of a cDNA encoding the precursor of human cytochrome c1. Fukuyama et al. (1991) regionalized the assignment to 8q24 by fluorescence in situ suppression hybridization (FISH). By isotopic in situ hybridization, Duncan et al. (1994) assigned the CYC1 gene to 8q24.3.