Cytochrome P450 2B6 (CYP2B6)

Miles et al. (1988) reported the isolation of cDNA clones that seemed, on the basis of their sequence homology to the rat P450IIB1 cDNA, to be encoded by part of the human P450IIB subfamily. Evidence of alternative splicing at the CYP2B locus was presented. Yamano et al. (1989) demonstrated 2 anomalous cDNAs derived from the CYP2B locus on chromosome 19. Thum and Borlak (2000) investigated the gene expression of major human cytochrome P450 genes in various regions of explanted hearts from 6 patients with dilated cardiomyopathy and 1 with transposition of the arterial trunk and 2 samples of normal heart. mRNA for cytochrome 2B6 was predominantly expressed in the right ventricle. A strong correlation between tissue-specific gene expression and enzyme activity was found.