Cytochrome P450 2C18 (CYP2C18)

Cytochrome P450 2C18 is a member of the cytochrome P450 superfamily of enzymes. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP4217 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19.Cytochrome P450 2C19, a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.It is involved in the metabolism of several important groups of drugs including many proton pump inhibitors and antiepileptics.