DEAH Box Polypeptide 15 (DHX15)

DHX15 contains 7 consecutive motifs characteristic of ATP-dependent RNA helicases, as well as consensus sequences for structural motifs of a DNA/RNA helicase with a DEAH box. DBP1 was expressed as a 3.4-kb mRNA in all tissues tested. An additional larger transcript was observed in many tissues.mDEAH9 and Prp43 are 65% identical over a 500-amino acid region spanning the central helicase domain and C-terminal region, and that mDEAH9 and HRH2 were 98% identical in the helicase domain. When expressed in yeast, mDEAH9 complemented the Prp43 mutation specifically, although with less efficiency than the native yeast protein. mDEAH9 colocalizes with splicing factor SC35 in punctate nuclear speckles in mammalian cells, consistent with its predicted role as a pre-mRNA splicing factor.