Diacylglycerol Kinase Theta (DGKq)

Diacylglycerol kinase theta is an enzyme contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.The predicted 882-amino acid human protein is 90% identical to rat DGK-theta. Sequence analysis revealed that DGK-theta contains a pleckstrin homology domain and the conserved DGK putative catalytic domain. However, unlike other DGK isotypes, DGK-theta contains 3 rather than 2 cysteine-rich zinc-binding domains, an N-terminal proline- and glycine-rich region, and a RAS-associating domain.