Diacylglycerol Kinase Zeta (DGKz)

Diacylglycerol kinase zeta is an enzyme belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.Human DGK-zeta contains 2 zinc fingers, an ATP-binding site, and 4 ankyrin repeats near the C terminus. A unique feature, as compared with other DGKs, is the presence of a sequence homologous to the MARCKS phosphorylation site domain. Northern blot analysis of multiple tissues showed that DGK-zeta is expressed at highest levels in brain and muscle.