Dynein, Axonemal, Heavy Chain 17 (DNAH17)

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. DNAH17 is a heavy chain associated with axonemal dynein.By screening an adult testis cDNA library using DNEL1 (DNAH9) as probe, followed by 5-prime and 3-prime RACE, Milisav and Affara (1998) obtained a partial cDNA for DNAH17, which they called DNEL2. Northern blot analysis detected a 16-kb transcript in testis. RT-PCR showed DNAH17 expression in adult testis, but not in any other adult or fetal tissue examined, including fetal testis.By FISH and radiation hybrid analysis, Milisav and Affara (1998) mapped the DNAH17 gene to chromosome 17q25.