Dynein, Cytoplasmic 1, Intermediate Chain 2 (DYNC1I2)

Cytoplasmic dynein is a minus end-directed microtubule motor composed of 2 catalytic heavy chains and accessory subunits, including intermediate and light intermediate chains. The 2 Chlamydomonas flagellar dynein intermediate chains (ICs) have been localized to the base of the dynein complex and bind directly to the A-microtubule of the flagellar outer doublet. Based on homology with the Chlamydomonas flagellar dynein ICs, they proposed a role for cytoplasmic dynein ICs in linking the motor protein to organelles and kinetochores. The predicted human and rat IC2 proteins are 94% identical. The predicted protein is 99% and 77% identical to rat Dnci2 and human DNCI1, respectively. Northern blot analysis indicated that Dnci2 was expressed broadly in all mouse tissues tested.