Fibronectin Leucine Rich Transmembrane Protein 1 (FLRT1)

FLRT1 shares 55% amino acid sequence identity with FLRT3 and 41% identity with FLRT2. Recombinant FLRT1 expressed in SF9 insect cells and monkey COS-1 cells migrated as a 90-kD protein on SDS-polyacrylamide gels. The authors demonstrated that FLRT1 is glycosylated.Northern blot analysis of a variety of human adult and fetal tissues detected a major 4.4-kb FLRT1 transcript only in adult and fetal brain and kidney. Within adult brain, FLRT1 expression was found in all subregions examined, namely putamen, temporal lobe, frontal lobe, occipital lobe, medulla, cortex, cerebellum, and spinal cord; besides the 4.4-kb transcript, an additional 6-kb FLRT1 transcript was present in all subregions except cerebellum.