GTP Binding Protein 1 (GTPBP1)

GTPBP1 is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype.Senju and Nishimura (1997) carried out PCR-based cDNA subtraction and subsequent differential display on mRNA isolated from a human monocytic leukemia cell line, THP-1. They detected a novel gene encoding a protein bearing GTP-binding motifs characteristic of G proteins. They also identified the mouse homolog of this gene and designated the gene GP1. The predicted 584-amino acid human protein is 97% identical to the mouse homolog.