Glycosylphosphatidylinositol Anchored Molecule Like Protein (GML)

Furuhata et al. (1996) identified a gene encoding a predicted 158-amino acid protein that is induced by p53 . Because of its homology to glycosylphosphatidylinositol (GPI)-anchored membrane proteins, Furuhata et al. (1996) designated the gene """GPI-anchored molecule-like protein,""" or GML. By Northern blot and RT-PCR analysis, Furuhata et al. (1996) found that GML is expressed as a less than 1-kb mRNA in many tissues, including testis.Expression of GML suppressed the growth of esophageal cancer cells in culture. Furuhata et al. (1996) suggested that GML may play a role in the apoptotic pathway or cell cycle regulation induced by p53 after DNA damage.Kimura et al. (1997) found that the GML gene consists of 4 exons spanning 12 kb, with a p53-binding site 19 kb upstream of the first exon.