Histone Cluster 1, H1t (HIST1H1T)

HIST1H1T is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. The rat H1t locus cosegregated with blood pressure in an F2 population derived from a cross of the Dahl salt-sensitive strain and the Lewis strain. Thus, H1t in rat is a quantitative trait locus for blood pressure.By study of somatic cell hybrids and by in situ hybridization, H1T gene is located in a cluster with 5 other H1 histone genes on chromosome 6p22.2-p21.1. Albig et al. (1997) mapped the H1FT gene to chromosome 6p21.3 within a cluster of 35 histone genes, including H1.1 (HIST1H1A) to H1.4 (HIST1H1E).