Histone Cluster 2, H2bf (HIST2H2BF)

HIST2H2BF encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.This intronless gene encodes a polypeptide of 126 amino acids. This H2B gene is paired with a functional H2A histone gene, and the 2 genes are separated by a bidirectionally transcribed intergenic promoter region of 329 nucleotides containing consensus TATA and CCAAT boxes and an OTF-1 element. The 3-prime untranslated region of the H2B.1 gene contains the conserved histone 3-prime stem-loop motif commonly found in cell cycle-dependent histone genes, as well as a polyadenylation signal typical of constitutively expressed histone genes.