Kelch Like Protein 7 (KLHL7)

KLHL7 protein contains a predicted N-terminal BTB domain, a BACK domain, and a C-terminal region containing Kelch repeats, and at least 1 potential monopartite nuclear localization signal. The rat Klhl7 protein shares 97.8% and 99.4% sequence identity with the human and mouse orthologs, respectively. Dot-blot analysis detected KLHL7 mRNA in all human tissues and cancer cell lines tested, with highest expression in adult and fetal heart, adult and fetal nervous system, and adult testis. Immunohistochemical studies of human brain tissues localized KLHL7 to the nuclei of neurons, including pyramidal cells of the hippocampus and cerebral cortex, cerebellar Purkinje cells, posterior root ganglion cells, and spinal cord anterior horn cells.