LIM And Calponin Homology Domains Containing Protein 1 (LIMCH1)

LIMCH1 contains one CH (calponin-homology) domain and one LIM zinc-binding domain. There are nine named isoforms. The calponin homology (CH) domain is a protein module of about 100 residues that was first identified at the N-terminus of calponin, an actin-binding protein playing a major regulatory role in muscle contraction. Three major groups of CH-domain-containing proteins have been recognized on the basis of sequence analysis. Proteins containing a single N-terminal CH domain (1xCH proteins) include calponin itself as well as signaling proteins such as Vav, IQGAP and Cdc24. Proteins with an F-actin-binding domain (ABD) composed of two CH domains in tandem (2xCH proteins) include spectrins, dystrophin, filamins and plakins.