Late Cornified Envelope Like Proline Rich Protein 1 (LELP1)

By searching for genes in a region of chromosome 1q21 associated with atopic dermatitis (ATOD2), Sharma et al. (2007) identified LELP1.By genomic sequence analysis, Sharma et al. (2007) mapped the LELP1 gene to chromosome 1q21.Interestingly, locus 5 is 6.2 kb upstream of a late cornified envelope-like proline-rich 1 (LELP1) gene which encodes a novel small proline rich protein. a significant association of rs7534334 (tagged SNP from LELP1) SNP with log10 serum IgE levels in the patient group (P = 0.0029). a chromosomal region in close proximity to a novel gene and highlight the need for intense research on LELP1 and other genes close by with respect to atopic disorders.