Lectin, Mannose Binding 2 (LMAN2)

By searching an EST database for sequences similar to dog Vip36, Neve et al. (2003) identified LMAN2, which they called VIP36. The deduced 356-amino acid protein contains an N-terminal signal sequence, followed by a lectin-type carbohydrate recognition domain and a C-terminal transmembrane domain. A KRFY endoplasmic reticulum trafficking motif is located at the C terminus. Northern blot analysis detected variable expression of 1.2- and 1.4-kb VIP36 transcripts in all tissues examined. Highest expression was in kidney, placenta, and liver.Nufer et al. (2003) determined that the LMAN2 gene contains 8 exons and spans 14.9 kb.By genomic sequence analysis, Nufer et al. (2003) mapped the LMAN2 gene to chromosome 5q35.5.