Leucine Rich Repeat Containing G Protein Coupled Receptor 6 (LGR6)

LGR6 encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.The deduced 846-amino acid LGR6 protein is approximately 46% identical to LGR4 and LGR5 . It contains 13 LRRs, an N-glycosylation site, and a C-flanking cysteine-rich hinge region in its N-terminus; the 7-transmembrane region; and a unique C-terminal tail. Northern blot analysis revealed wide expression of a predominant 4.0-kb transcript in rat tissues.