Leucine Rich Repeat Neuronal Protein 2 (LRRN2)

LRRN2 belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.The protein appears to be a transmembrane protein belonging to the leucine-rich repeat (LRR) superfamily. GAC1 contains 12 full-length LRR motifs, and its LRR block is flanked by cysteine-rich sequences. It also contains 4 potential N-linked glycosylation sites and a C-terminal cytoplasmic region of 63 amino acids.