Leucine Rich Repeat Transmembrane Neuronal 2 (LRRTM2)

LRRTM2 contains an N-terminal signal sequence, followed by 10 extracellular LRRs flanked by cysteine-rich domains, a transmembrane region, and an intracellular tail. LRRTM2 has 5 N-glycosylation sites, several putative phosphorylation sites, and a C terminus that ends in the sequence ECEV, which is a characteristic of LRRTM family members. RT-PCR analysis detected prominent LRRTM2 expression in human brain, including amygdala, caudate nucleus, cerebellum, corpus callosum, hippocampus, and thalamus, and lower expression in all other human tissues examined except bone marrow. In developing mice, Lrrtm2 expression began at embryonic day 15, increased at postnatal day 1, and remained high into adulthood. In situ hybridization of adult mouse brain detected widespread Lrrtm2 expression predominantly in neurons.