Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3)

The deduced 513-amino acid protein contains an N-terminal signal sequence, followed by 10 extracellular LRRs flanked by cysteine-rich domains, a transmembrane region, and an intracellular tail. LRRTM3 has 3 N-glycosylation sites, several putative phosphorylation sites, and a C terminus that ends in the sequence ECEV, which is a characteristic of LRRTM family members. RT-PCR analysis of human tissues detected LRRTM3 expression restricted to whole brain, including amygdala, caudate nucleus, cerebellum, corpus callosum, hippocampus, and thalamus. In developing mice, Lrrtm3 was expressed at embryonic day 13 and 15, reaching highest levels at postnatal day 1 that persisted into adulthood. In situ hybridization of adult mouse brain detected widespread Lrrtm3 expression predominantly in neurons.