Leukotriene B4 Receptor 2 (LTB4R2)

Leukotriene B4 receptor 2 is a low-affinity receptor for leukotrienes, especially leukotriene B4. Leukotriene B4 (LTB4) is an arachidonic acid metabolite and one of the most potent activators of phagocytes. LTB4 binds to a G protein-coupled receptor (GPCR) termed BLT1 (LTB4R) and activates the Gi and G16 classes of G proteins. Overproduction of LTB4 is involved in several inflammatory diseases. BLT2 is located in the promoter region of LTB4R. The deduced 358-amino acid protein is 93% identical to the mouse sequence and 45% identical to LTB4R. Northern blot analysis revealed ubiquitous expression of a major 2.5-kb BLT2 transcript, as well as longer transcripts, with strongest expression in spleen, followed by liver, ovary, and leukocytes. In contrast, LTB4R expression is restricted to leukocytes.