Lysophospholipid Acyltransferase 2 (LPLAT2)

Hishikawa et al. (2008) cloned mouse Mboat2, which they called Lpcat4. The deduced 519-amino acid protein contains 4 putative transmembrane domains. RT-PCR detected high Lpcat4 expression in epididymis, brain, testis, and ovary. Lpcat4 colocalized with an endoplasmic reticulum marker protein in transfected Chinese hamster ovary cells.Hishikawa et al. (2008) found that mouse Lpcat4 converted lysophosphatidylcholine and lysophosphatidylethanolamine to phosphatidylcholine and phosphatidylethanolamine, respectively, and preferred oleoyl-CoA as the acyl donor.The International Radiation Hybrid Mapping Consortium mapped the MBOAT2 gene to chromosome 2.