Myosin ID (MYO1D)

Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. For further background information on myosins.By screening for cDNAs with the potential to encode large proteins expressed in brain, Nagase et al. (1998) identified a cDNA encoding MYO1D, which they called KIAA0727. The deduced 674-amino acid protein is 98% identical to rat Myr4. RT-PCR analysis detected expression of KIAA0727 in all tissues tested, with highest levels in brain, followed by lung and ovary; expression was lowest in spleen. By radiation hybrid analysis, Nagase et al. (1998) mapped the MYO1D gene to chromosome 17. Hasson et al. (1996) mapped the mouse gene to chromosome 11 by interspecific backcross analysis and predicted a localization of 17q11-q12 in human.