Myosin IF (MYO1F)

Kim et al. (2006) demonstrated that MYO1F is expressed predominantly in the mammalian immune system. Cells from Myo1f-deficient mice exhibited abnormally increased adhesion and reduced motility, resulting from augmented exocytosis of beta-2 integrin-containing granules. In addition, the cortical actin that colocalizes with Myo1f was reduced in Myo1f-deficient cells. In vivo, Myo1f-deficient mice showed increased susceptibility to infection by Listeria monocytogenes and an impaired neutrophil response. Thus, Kim et al. (2006) concluded that Myo1f directs immune cell motility and innate host defense against infection.The deduced 1,099-amino acid protein is 91% identical to the mouse protein. Northern blot analysis revealed wide expression of Myo1f in adult mouse tissues.