Myosin Light Chain 4, Alkali, Atrial, Embryonic (MYL4)

Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.By Southern blot analysis of DNA from somatic cell hybrids, Cohen-Haguenauer et al. (1989) assigned the MYL4 gene (which codes the atrial/fetal muscle isoform of myosin alkali light chains) to chromosome 17. The corresponding gene in the mouse has been assigned to chromosome 11.