Myosin VB (MYO5B)

Recent evidence suggests that Myosin VB is related to the creation of memories.KIAA1119. The deduced 1,260-amino acid protein is 88% identical to rat Myr6. RT-PCR analysis detected wide expression of KIAA1119, with highest levels in liver, followed by kidney.Roland et al. (2007) demonstrated the interaction of MYO5B with RAB8A in yeast 2-hybrid assays, and confirmed the interaction of MYO5B with RAB11A and RAB8A in vivo using fluorescent resonant energy transfer techniques.Muller et al. (2008) noted that MYO5B is required for the recycling of transferrin receptor back to the plasma membrane through an endocytotic recycling compartment in nonpolarized, but not polarized, cells.