Myozenin 1 (MYOZ1)

Calcineurin is a calcium/calmodulin-dependent serine-threonine phosphatase that plays an important role in transducing calcium-dependent signals in a variety of cell types. Calcineurin has also been shown to have a profound influence on the properties of striated muscle cells, including cardiac muscle.Calsarcin-2 encodes a 299-amino acid protein, which shows the highest sequence homology with calsarcin-1 in the N and C termini. Calsarcins 1 and 2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle as 1.6- and 2.6-kb transcripts, whereas calsarcin-2 is expressed only in adult fast skeletal muscle as a 1.6-kb transcript.