Non SMC Condensin II Complex Subunit G (NCAPG)

In contrast to most genomic DNA in mitotic cells, the promoter regions of some genes, such as the stress-inducible hsp70i gene that codes for a heat-shock protein, remain uncompacted, a phenomenon known as bookmarking. Xing et al. (2005) showed that hsp70i bookmarking is mediated by a transcription factor called HSF2, which binds this promoter in mitotic cells, recruits protein phosphatase 2A, and interacts with the CAPG subunit of the condensin enzyme to promote efficient dephosphorylation and inactivation of condensin complexes in the vicinity, thereby preventing compaction at this site.RT-PCR and Northern blot analyses showed highest expression of CAPG in the testis among normal tissues and variable expression in tumor cells, reflecting the proliferative activity in these cells.