Nucleotide Binding Protein 1 (NUBP1)

NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins. The deduced 320-amino acid protein has a molecular mass of 34.5 kD. NBP displays sequence similarity with the product of the MinD gene from Escherichia coli. MinD is involved in the proper placement of the division septum and has ATPase activity. Both NBP and MinD contain consensus nucleotide-binding domains. The NBP mRNA is approximately 1,500 nucleotides long and was expressed in several human cell lines and in all rat tissues examined, with the highest levels in lung and testis. Shahrestanifar et al. (1994) indicated that the yeast homolog of the NBP gene had been isolated and found to exhibit 40% identity with human NBP. Furthermore, mutation of the gene was found to be lethal in yeast, indicating that NBP plays a vital role in cell function.