Oxidation Resistance 1 (OXR1)

In a search for human genes that function in protection against oxidative damage, Volkert et al. (2000) identified the human OXR1 (oxidation resistance-1) gene. The method used to identify the gene involved transforming E. coli oxidation repair-defective spontaneous mutator strains with a human cDNA library and screening transformants for a reduction in mutator activity. OXR1 is a member of a conserved family of genes found in eukaryotes but not in prokaryotesVolkert et al. (2000) determined that the OXR1 gene contains 9 exons. The first exon includes 74 bp of upstream untranslated sequence present in the cDNA, and the last exon includes 156 bp of downstream untranslated DNA sequence.