Oxysterol Binding Protein Like Protein 10 (OSBPL10)

OSBPL10 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Sequence analysis predicted that the 764-amino acid protein contains a C-terminal sterol-binding (SB) domain of approximately 400 residues that includes the OSBP motif (EQVSHHPP). It has a pleckstrin homology (PH) domain in its N terminus. OSBPL10 is 75% and 58% identical to OSBPL11 in the SB and PH domains, respectively. Dot blot analysis revealed wide expression that was strongest in kidney and placenta, followed by heart, skeletal muscle, liver, small intestine, spleen, lung, and testis.