Oxysterol Binding Protein Like Protein 11 (OSBPL11)

Oxysterol-binding protein-related protein 11 is a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain.Sequence analysis predicted that the 747-amino acid protein contains a C-terminal sterol-binding (SB) domain of approximately 400 amino acids that includes the OSBP motif (EQVSHHPP). It has a pleckstrin homology (PH) domain in its N terminus. OSBPL11 is 75% and 58% identical to OSBPL10 in the SB and PH domains, respectively. Gene expression database analysis indicated highest expression in lung and spleen, followed by brain, liver, and placenta.