Oxysterol Binding Protein Like Protein 5 (OSBPL5)

OSBPL5 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.Sequence analysis predicted that the 879-amino acid protein contains a C-terminal sterol-binding (SB) domain of approximately 400 residues that includes the OSBP motif (EQVSHHPP). It has a pleckstrin homology (PH) domain in its N terminus. OSBPL5 is 78% and 88% identical to OSBPL8 in the SB and PH domains, respectively. The deduced 863-amino acid protein was predicted to be 34% identical to mouse Osbp. RT-PCR analysis detected wide expression that was strongest in ovary and in various brain regions.