Oxysterol Binding Protein Like Protein 7 (OSBPL7)

OSBPL7 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Two transcript variants encoding the same isoform have been identified. Sequence analysis predicted that the 842-amino acid protein contains a C-terminal sterol-binding (SB) domain of approximately 400 residues that includes the OSBP motif (EQVSHHPP).It has a pleckstrin homology (PH) domain in its N terminus. OSBPL7 is approximately 76% identical to OSBPL3 and OSBPL6 in the SB domain and 62% and 69% identical, respectively, in the PH domain. Dot blot analysis revealed wide expression that was strongest in small intestine and colon, followed by thymus, spleen, and peripheral blood leukocytes.