Oxysterol Binding Protein Like Protein 8 (OSBPL8)

OSBPL8 is a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.The deduced 488-amino acid protein was predicted to be 33% identical to mouse Osbp. RT-PCR analysis detected wide expression that was strongest in testis, ovary, liver, kidney, and brain. Within brain, expression was particularly strong in caudate nucleus.Sequence analysis predicted that the 847-amino acid protein contains a C-terminal sterol-binding (SB) domain of approximately 400 residues that includes the OSBP motif (EQVSHHPP).