Oxysterol Binding Protein Like Protein 9 (OSBPL9)

OSBPL9 encodes a member of the OSBP family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Multiple transcript variants, most of which encode distinct isoforms, have been identified.Sequence analysis predicted that the 558-amino acid protein contains a C-terminal sterol-binding (SB) domain of approximately 400 residues that includes the OSBP motif (EQVSHHPP). OSBPL9 appears to be in a distinct OSBP subfamily and shares relatively little homology in the SB domain with other OSBPs. Gene expression database analysis indicated highest expression in brain and spleen, followed by heart, skeletal muscle, placenta, and testis.