Peroxidasin Like Protein (PXDNL)

PXDNL belongs to the peroxidase family. PXDNL is moderately expressed, only 28.6% of the average gene in this release, PXDNL contains 23 different gt-ag introns.XPO subfamily. Dysfunction of mitochondria in nerve cells contributes to the neurodegeneration of PD. When cells are infected by the CMV virus, they become resistant to certain mitochondrial toxins that may be important in causing PD. CMV-infected cells produce very high levels of a protein called PXDNL about which very little is known. PXDNL is selectively found in substantia nigra neurons, increasing its levels will detoxify the free radicals produced by malfunctioning mitochondria and thereby protect these neurons. PXDNL may protect against these toxic processes and, if so, it may open the way for a new approach to slowing or halting the progression of the disease.