Phospholipase C Like Protein 1 (PLCL1)

Kohno et al. (1995) noted that the presence of a tumor suppressor gene in the 2q33 region had been suggested by a high incidence of allelic loss on 2q in lung carcinoma and the finding of a homozygous deletion at 2q33 in a small cell lung carcinoma cell line. They constructed a cosmid contig covering the homozygous deleted region, estimated at 220 kb, and identified a novel gene within this region. Since the gene encodes a protein with striking similarity to several members of a family of phospholipase C, they designated the gene PLCL for """phospholipase C-deleted in lung carcinoma.""" The PLCL gene was expressed in a variety of fetal and adult organs, including the lung. However, its expression was greatly reduced in 7 of 13 (53.8%) small cell lung carcinoma and 13 of 15 (86.7%) nonsmall cell lung carcinoma cell lines.