Plastin 1 (PLS1)

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5""" UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11. The predicted 629-amino acid protein is 86%, 75%, and 73% identical to chicken fimbrin, human T-plastin (PLS3), and L-plastin (LCP1), respectively. I-plastin migrated as a 68-kD protein on Western blots of human small intestine and colon extracts.