Protein Phosphatase 1, Catalytic Subunit Gamma Isoform (PPP1CC)

The nucleotide sequence contained a 957-nucleotide open reading frame encoding an amino acid sequence identical to that encoded by the rat liver cDNA. Northern blot analysis showed that PPP1G-specific mRNA is expressed in human heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.This strategy to find fertility factors conserved from C. elegans to mammals achieved its goal: of mouse gene knockouts corresponding to nematode proteins, 37% (7 of 19) cause male sterility. This list includes PPP1CC, H2AX , SON, TOP1, DDX4, DBY, and CENPC. (The PPP1A gene (more appropriately symbolized PPP1CA) is located on chromosome 11. The PPP1CB gene is located on 2p23.) PPP1CC gene maps to human 12q24.1-q24.2, rat 7q22, and mouse 10C.