Protein Phosphatase 1, Regulatory Subunit 11 (PPP1R11)

Protein phosphatase 1 regulatory subunit 11 is a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6.The predicted 126-amino acid PPP1R11 protein contains 8 potential phosphorylation sites and a C-terminal PEST pattern that is characteristic of proteins with short half-lives. PPP1R11 shares 89.7% amino acid identity with its mouse homolog, Tctex5. PPP1R11 is a specific inhibitor of PP1 with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1.PPP1R11 is well conserved in evolution, with related genes in S. cerevisiae, S. pombe, and C. elegans.