Protein Phosphatase 2, Catalytic Subunit Beta Isoform (PPP2Cb)

PPP2Cb encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. Two transcript variants encoding the same protein have been identified for this gene.Hemmings et al. (1988) isolated the human cDNA for the beta-isoform of the catalytic subunit of protein phosphatase 2A (PPP2CB) from lung and lung fibroblast libraries. The cDNA encodes a 309-amino acid polypeptide.