Scavenger Receptor Class A Member 5 (SCARA5)

Scara5, encoding a deduced 491-amino acid protein that shares 88% sequence identity with the 495-amino acid human ortholog. Although overall identity with Scara1 is about 25%, Scara5 and Scara1 share many features, including an N-terminal cytoplasmic domain followed by a predicted transmembrane domain, a spacer region with several putative glycosylation sites, a collagenous domain, a hinge region, and a C-terminal scavenger receptor cysteine-rich domain (SRCR). The SCARA5 protein was predicted to be trimeric, as are other collagenous transmembrane proteins, and this prediction was supported by Western blotting. Based on similarity to other members of this family, the trimer is present on the surface of the plasma membrane and anchored by the transmembrane domain.