Secretoglobin Family 3A, Member 2 (SCGB3A2)

In addition to regulating thyroid-specific expression of genes, thyroid transcription factor (TITF1) controls the transcription of genes specifically expressed in lung, such as surfactant proteins and uteroglobin (UGB). Mice lacking Ttf1 die immediately after birth from respiratory failure caused by profoundly hypoplastic lungs. The UGRP1 gene encodes a uteroglobin-related protein and is a downstream target of TITF1.The deduced 93-amino acid UGRP1 protein is 81% identical to the mouse protein. Northern blot analysis revealed expression of a 0.5-kb transcript in mouse lung, with weak expression in thyroid. Western blot analysis showed expression of an approximately 14-kD protein. Immunohistochemical analysis demonstrated staining of epithelial cells of mouse embryonic lung trachea, bronchus, and bronchioles.