Small Proline Rich Protein 2D (SPRR2D)

Sprr2d is 1 of 11 highly homologous mouse Sprr2 genes (Sprr2a-k) clustered on chromosome 3, which encode a family of small proline-rich proteins (SPRRs). SPRR2 proteins appear to be present in a variety of mammalian species. SPRRs are principally expressed during the terminal differentiation of stratified squamous epithelia and are proposed to be structural components of cornified envelopes. In adult mice, Sprr2 genes are expressed in squamous cells of the skin, footpad, vaginal epithelia, digestive tract, and respiratory epithelia. In adult mice, 1700106J16Rik expression appears to be largely restricted to testis and spinal cord . 1700106J16Rik and Sprr2d expression during embryonic development previously has not been characterized. Expression of Sprr2d was independently shown to be ovary-biased in E11.5 gonads .