Small Proline Rich Protein 3 (SPRR3)

Gibbs et al. (1993) showed that the SPRR proteins are encoded by closely related members of a gene family, consisting of 2 genes for SPRR1 (SPRR1A and SPRR1B), approximately 7 genes for SPRR2, and a single gene for SPRR3. All SPRR genes are closely linked within a 300-kb DNA segment on 1q21-q22, a region where the related loricrin and involucrin genes have also been mapped. By pulsed-field gel electrophoresis analysis, Gibbs et al. (1993) concluded that the SPRR1 genes are located between the SPRR2 genes and the SPRR3 gene.Gibbs et al. (1993) concluded that there is a single gene for the SPRR3 subfamily of small proline-rich proteins. All SPRR genes are closely linked within a 300-kb DNA segment on 1q21-q22.