Stomatin Like Protein 2 (STOML2)

STOML2 has 3 potential initiator sites, all sharing the same open reading frame. The STOML2 protein contains the cognate stomatin family consensus sequence, but it lacks the characteristic N-terminal hydrophobic domain and palmitoylation consensus sequence. STOML2 shares greatest sequence homology with stomatin and SLP1 in a region predicted to contain beta-sheet and alpha-helix structures. STOML2 transcript in all tissues examined, with highest levels in heart, liver, and pancreas. Some cells also showed a faint band at about 34.3 kD, which may represent translation from an alternate initiation site. STOML2 partitioned into both Triton X-100-soluble and -insoluble pools in erythrocyte ghost membranes or following expression in COS cells.